Altman Daniel, Ekström Asa, Gustafsson Catharina, López Annika, Falconer Christian, Zetterström Jan
Pelvic Floor Center, Department of Obstetrics and Gynecology, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden.
Obstet Gynecol. 2006 Oct;108(4):873-8. doi: 10.1097/01.AOG.0000233172.96153.ad.
To estimate prospectively the effect of first delivery on subjective bladder function and to assess the influence of subsequent deliveries and obstetric events
We performed a prospective, observational cohort study. During a 10-week period in 1995, 304 of 309 eligible primiparous women (98%) entered the study at the postpartum maternity ward and completed a bladder function questionnaire. The 10-year observational period was completed by 246 of 304 subjects (81%).
Prevalence of moderate-severe stress urinary incontinence increased from 5 of 304 subjects (2%) at baseline to 27 of 229 (12%) at 10 years follow-up (P < .001). Prevalence of moderate-severe urinary urgency increased from 0 subjects (0%) at baseline to 31 of 229 (13%) at the 10-year follow-up (P < .001). The relative risk (RR) (adjusted for maternal age and parity) of moderate to severe urinary incontinence increased significantly 10 years after first delivery (RR 5.8, 95% confidence interval [CI] 1.2-33.7). At multivariable analysis adjusted for age and parity, stress urinary incontinence symptoms at 9 months and 5 years follow-up were independently associated with the presence of symptoms at 10 years after index delivery (RR 13.3, 95% CI 3.9-33.1 and RR 14.1, 95% CI 2.5-18.8, respectively). Number of vaginal deliveries or other obstetric covariates did not affect the risk of stress urinary incontinence or urinary urgency.
Vaginal delivery is independently associated with a significant long-term increase in stress urinary incontinence symptoms, as well as urinary urgency, regardless of maternal age or number of deliveries.
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前瞻性评估首次分娩对主观膀胱功能的影响,并评估后续分娩及产科事件的影响。
我们进行了一项前瞻性观察队列研究。1995年的10周期间,309名符合条件的初产妇中有304名(98%)在产后产科病房进入研究,并完成了膀胱功能问卷。304名受试者中的246名(81%)完成了10年的观察期。
中度至重度压力性尿失禁的患病率从基线时304名受试者中的5名(2%)增至10年随访时229名中的27名(12%)(P <.001)。中度至重度尿急的患病率从基线时0名受试者(0%)增至10年随访时229名中的31名(13%)(P <.001)。首次分娩10年后,中度至重度尿失禁的相对风险(RR)(根据产妇年龄和胎次调整)显著增加(RR 5.8,95%置信区间[CI] 1.2 - 33.7)。在根据年龄和胎次进行多变量分析时,9个月和5年随访时的压力性尿失禁症状与首次分娩后10年的症状存在独立关联(RR分别为13.3,95% CI 3.9 - 33.1和RR 14.1,95% CI 2.5 - 18.8)。阴道分娩次数或其他产科协变量不影响压力性尿失禁或尿急的风险。
无论产妇年龄或分娩次数如何,阴道分娩与压力性尿失禁症状以及尿急的显著长期增加独立相关。
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