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A new model for translational regulation of specific mRNAs.

作者信息

Tettweiler Gritta, Lasko Paul

机构信息

Department of Biology and DBRI, McGill University, 1205 Avenue Dr. Penfield, Montréal, Québec H3A 1B1, Canada.

出版信息

Trends Biochem Sci. 2006 Nov;31(11):607-10. doi: 10.1016/j.tibs.2006.09.008. Epub 2006 Oct 2.

DOI:10.1016/j.tibs.2006.09.008
PMID:17015016
Abstract

Recently, RNA helicase A (RHA) has been shown to facilitate translation of specific mRNAs by recognizing and binding to a complex structure at their 5' end known as the post-transcriptional control element. This implicates RHA, a member of the DEXD/H-box protein superfamily, in linking transcription and translation of a specific class of retroviral and cellular mRNAs. This exciting finding suggests a new mechanism for the regulation of the translation of specific transcripts.

摘要

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