Hoso M, Nakanuma Y
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Liver. 1990 Oct;10(5):264-8. doi: 10.1111/j.1600-0676.1990.tb00468.x.
Mallory bodies are known to occur in hepatocellular carcinoma. The simple question whether or not there are any clinicopathological features characterizing Mallory body-positive hepatocellular carcinoma remains unresolved to date. The present study of 200 consecutive autopsy cases of hepatocellular carcinoma showed several important differences between 49 cases bearing Mallory bodies and 151 cases bearing no Mallory bodies in carcinoma cells. The patients in the former group were older, showed a higher association rate of liver cirrhosis, and their liver weight was lighter. As to the gross pathology of hepatocellular carcinoma, the nodular type was relatively frequent in Mallory body-positive hepatocellular carcinoma, while the massive and diffuse types were relatively frequent in Mallory body-negative cases. The frequency of extrahepatic metastases in the Mallory body-positive group was lower than that in the Mallory body-negative cases. The reasons for these differences remain speculative.
已知马洛里小体出现在肝细胞癌中。迄今为止，关于马洛里小体阳性肝细胞癌是否具有任何临床病理特征这一简单问题仍未得到解决。本研究对200例连续的肝细胞癌尸检病例进行分析，结果显示，49例癌细胞中含有马洛里小体的病例与151例不含马洛里小体的病例之间存在若干重要差异。前一组患者年龄较大，肝硬化的关联率较高，肝脏重量较轻。关于肝细胞癌的大体病理，结节型在马洛里小体阳性肝细胞癌中相对常见，而巨块型和弥漫型在马洛里小体阴性病例中相对常见。马洛里小体阳性组肝外转移的发生率低于马洛里小体阴性病例。这些差异的原因仍属推测。
