Rodríguez-Morán Martha, Guerrero-Romero Fernando
Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute, Durango, Mexico.
Pediatrics. 2006 Nov;118(5):e1516-22. doi: 10.1542/peds.2006-0845. Epub 2006 Oct 2.
Our goal was to determine the relationship between family history of type 2 diabetes and fasting hyperinsulinemia in healthy children and adolescents.
A total of 317 children and adolescents, 10 to 14 years of age with Tanner stage 1 or 2, were randomly selected from elementary and middle schools in Durango, northern Mexico, to participate in a cross-sectional, community-based study. Family history was ascertained by a direct, detailed medical examination that included anthropometric and laboratory measurements from both parents. We determined the prevalence of family history of type 2 diabetes, high blood pressure, obesity, hyperinsulinemia, and the adjusted odds ratio that computes the relationship between hyperinsulinemia and family history of type 2 diabetes.
Family history of type 2 diabetes, high blood pressure, and obesity was recognized in 30 (9.2%), 61 (18.7%), and 74 (22.7%) children and adolescents, respectively. Children and adolescents with positive family history showed higher systolic and diastolic blood pressure, were more obese, and exhibited significantly higher fasting insulin and triglycerides levels, as well as a higher homeostasis model analysis insulin resistance index, than children with negative family history. A total of 48 (15.1%) children and adolescents exhibited hyperinsulinemia, 35 (72.9%) with and 13 (27.1%) without family history. The odds ratio adjusted by gender, fat mass (kilograms and percent), waist circumference, BMI, and Tanner stage showed that family history of diabetes, but not high blood pressure and obesity, was independently related with hyperinsulinemia.
Among children and adolescents, family history of diabetes, but not high blood pressure and obesity, is independently associated with hyperinsulinemia.
我们的目标是确定健康儿童和青少年2型糖尿病家族史与空腹高胰岛素血症之间的关系。
从墨西哥北部杜兰戈市的中小学中随机选取了317名10至14岁、坦纳分期为1或2期的儿童和青少年，参与一项基于社区的横断面研究。通过直接、详细的医学检查确定家族史，该检查包括对父母双方进行人体测量和实验室检测。我们确定了2型糖尿病、高血压、肥胖、高胰岛素血症家族史的患病率，以及计算高胰岛素血症与2型糖尿病家族史之间关系的调整比值比。
分别有30名（9.2%）、61名（18.7%）和74名（22.7%）儿童和青少年被确认有2型糖尿病、高血压和肥胖家族史。有阳性家族史的儿童和青少年收缩压和舒张压更高，更肥胖，空腹胰岛素和甘油三酯水平显著更高，稳态模型分析胰岛素抵抗指数也更高，高于无家族史的儿童。共有48名（15.1%）儿童和青少年出现高胰岛素血症，其中35名（72.9%）有家族史，13名（27.1%）无家族史。经性别、脂肪量（千克和百分比）、腰围、体重指数和坦纳分期调整后的比值比显示，糖尿病家族史而非高血压和肥胖家族史与高胰岛素血症独立相关。
在儿童和青少年中，糖尿病家族史而非高血压和肥胖家族史与高胰岛素血症独立相关。
