Maurits Natasha M, Scheeringa Rene, van der Hoeven Johannes H, de Jong Ritske
Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands.
J Clin Neurophysiol. 2006 Oct;23(5):395-403. doi: 10.1097/01.wnp.0000219410.97922.4e.
Changes in coherence with aging during cognitive tasks have, until now, not been investigated. However, several fMRI and positron emission tomography studies of cognitive tasks have found increased bilateral activity in elderly subjects. Changes in coherence with aging during a cognitive task were investigated to see if EEG coherence was present in older adults. An auditory oddball task, which is a widely used test for cognitive function, was used. Eleven young adults (27.8 +/- 4.8 years, six females) and 10 older adults (61.3 +/- 4.6 years, six females) were studied, and both interhemispheric and long- and short-range intrahemispheric coherence were considered. Higher interhemispheric coherence was found in the older subjects in the delta band. Short intrahemispheric coherence was also increased in the theta, delta, and alpha bands. Higher coherence, although not significantly different, was also found for all other coherence types and bands, except for long intrahemispheric coherence in the low gamma band. The results presented here provide the first evidence that aging is associated with increased EEG coherence during a relatively easy cognitive task.
迄今为止，尚未对认知任务期间与衰老相关的连贯性变化进行研究。然而，多项关于认知任务的功能磁共振成像（fMRI）和正电子发射断层扫描研究发现，老年受试者的双侧活动增加。本研究调查了认知任务期间与衰老相关的连贯性变化，以探究老年人是否存在脑电图连贯性。采用了一种广泛用于认知功能测试的听觉Oddball任务。研究了11名年轻成年人（27.8±4.8岁，6名女性）和10名老年人（61.3±4.6岁，6名女性），并考虑了半球间以及半球内长程和短程连贯性。在老年受试者的δ波段中发现了更高的半球间连贯性。在θ、δ和α波段中，半球内短程连贯性也有所增加。除了低γ波段的半球内长程连贯性外，在所有其他连贯性类型和波段中也发现了更高的连贯性，尽管差异不显著。此处呈现的结果首次证明，在相对简单的认知任务期间，衰老与脑电图连贯性增加有关。
