O'Sullivan S E
University of Nottingham, School of Biomedical Sciences, University of Nottingham, Nottingham, Notts, UK. o'
Br J Pharmacol. 2006 Nov;149(6):609-10. doi: 10.1038/sj.bjp.0706907. Epub 2006 Oct 3.
The important role of nitric oxide (NO) in the regulation of vascular tone has been well studied. By contrast, the vascular significance of another gaseous mediator, hydrogen sulphide (H2S), is still poorly understood. A study published in this issue of the British Journal of Pharmacology now provides evidence that in addition to the vasorelaxant effects of H2S reported in vitro, low concentrations of H2S also cause arterial vasoconstriction, reverse NO-mediated vasorelaxation and cause an NO-dependent pressor effect in vivo. This commentary discusses the implications and questions raised by these results.
一氧化氮（NO）在调节血管张力方面的重要作用已得到充分研究。相比之下，另一种气体介质硫化氢（H₂S）的血管意义仍知之甚少。发表于本期《英国药理学期刊》的一项研究现在提供了证据，表明除了体外报道的H₂S的血管舒张作用外，低浓度的H₂S还会导致动脉血管收缩、逆转NO介导的血管舒张，并在体内引起NO依赖性升压效应。本评论讨论了这些结果所带来的影响和引发的问题。
