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生物电磁学研究领域的35年。

Thirty-five years in bioelectromagnetics research.

作者信息

Chou C-K

机构信息

Corporate EME Research Laboratory, Motorola Labs, Fort Lauderdale, FL 33322, USA.

出版信息

Bioelectromagnetics. 2007 Jan;28(1):3-15. doi: 10.1002/bem.20292.

Abstract

For 35 years, I have been involved in various bioelectromagnetics research projects including acute and long-term radiofrequency (RF) bioeffects studies, dosimetry, exposure systems, MRI safety, cancer studies involving hyperthermia and electrochemical treatment, development of RF exposure and measurement standards, and product compliance. My first study demonstrated that effects on isolated nerve and muscle preparations were due to thermal effects of RF exposure. The recording of cochlear microphonics in animals shows the mechanical nature of the microwave auditory effect. In 1992, we published the results of a large-scale lifetime study in which 100 rats were sham-exposed and 100 rats were exposed for 21 h/day for 25 months to a pulsed RF signal. In dosimetry studies, human models were employed as well as many animal species including mice, rats, rabbits, monkeys, and birds of many sizes. Cancer hyperthermia studies demonstrated that knowledge of temperature distribution was crucial for successful treatment. Research on electrochemical treatment of tumors with direct current involved cellular, animal, and clinical studies. Over the past few decades, there has been rather extensive investigation of the public health impact of RF exposure. In my opinion, future research in bioelectromagnetics should place greater emphasis on medical applications.

摘要

35年来,我参与了各种生物电磁学研究项目,包括急性和长期射频(RF)生物效应研究、剂量测定、暴露系统、磁共振成像安全、涉及热疗和电化学治疗的癌症研究、射频暴露和测量标准的制定以及产品合规性研究。我的第一项研究表明,对离体神经和肌肉制剂的影响是由于射频暴露的热效应。动物耳蜗微音器电位的记录显示了微波听觉效应的机械性质。1992年,我们发表了一项大规模终生研究的结果,其中100只大鼠接受假暴露,100只大鼠每天暴露21小时,持续25个月,暴露于脉冲射频信号。在剂量测定研究中,使用了人体模型以及许多动物物种,包括小鼠、大鼠、兔子、猴子和各种大小的鸟类。癌症热疗研究表明,温度分布知识对于成功治疗至关重要。用直流电对肿瘤进行电化学治疗的研究涉及细胞、动物和临床研究。在过去几十年里,人们对射频暴露对公众健康的影响进行了相当广泛的调查。在我看来,生物电磁学未来的研究应更加注重医学应用。

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