The fundamental law of electrostimulation and its application to defibrillation.

Around the turn of the last century, there was an intensive discussion among physiologists as to whether there is a law describing the phenomena of electrostimulation and which formula may best approximate it mathematically. J.L. Hoorweg found in 1892 that the voltage at which a capacitor must be charged to elicit an excitation, was a function of the capacitance in an inverse correlation. G. Weiss reported in 1901 that according to his investigations a linear relationship existed between the duration of a pulse and the corresponding quantity of electricity applied and called it "formule fondamentale." We are now able to give the "fundamental formula" a physical interpretation that yields, as result, the electric field produced by the electrode acting on the excitable membrane. The electric field in the extracellular space is transformed by the cell geometry ratio: cell length to membrane thickness yielding a high transmembrane field capable of reducing the inherent electric field to its threshold level. The consequences drawn from this hypothesis are remarkable and (should) have an influence on all applications of electrostimulation including the discussions on defibrillation. The application of the stimulation theory to defibrillation yields as results: (1) The basic engineering principle of defibrillation is to produce an electric field within the ventricles of 400 V/m or more. An orthogonal pulse application may reduce the energy requirements, as more fibers are longitudinally reached by the electric field; (2) The shape of the defibrillation pulse and its polarity plays no role. Consequently it follows that biphasic pulses must be less efficient than monophasic pulses, if they are close to the chronaxie; and (3) The most serious disadvantage in today's defibrillation practice is its dose characterization in "energy"; but this physical quantity cannot be justified in the light of the fundamental law of electrostimulation.