Ragnarsdóttir B, Jónasson J G, Tulinius H, Olafsson S
Department of Medicine, Landspitali University Hospital, Fossvogi, 108 Reykjavík, Iceland.
Laeknabladid. 2001 Jun;87(6):527-31.
The incidence of hepatocellular carcinoma (HCC) varies throughout the world, being relatively low in Northern Europe (less than five per 100,000 population) where the majority of the patients have cirrhosis. In Iceland the prevalence of viral hepatitis and cirrhosis, the main risk factors for HCC, is lower than reported in many other countries. The aim of our study was to investigate the incidence and etiology of HCC in Iceland.
All patients diagnosed with HCC in Iceland in 1984-1998 were included in the study. Histologic diagnosis was required for inclusion. Patients were identified from the Icelandic Cancer Registry and by reviewing autopsy and histopathology reports. Further information was obtained from medical records.
A total of 71 cases of HCC were identified, 51 males and 20 females. The mean age for males was 69.3 years (18-95) and 73 years (52-89) for females. The age-standardized annual incidence rate of HCC was 1.08/100,000 (males 2.10, females 0.67). The incidence did not increase significantly during the study period. Alcohol abuse (15.5%) and hemochromatosis (11%) were the most common risk factors. Twenty-three (32%) had cirrhosis but 39 (55%) had no known risk factors. Of 55 cases where non-neoplastic tissue was available for examination, 27 had liver disease.
肝细胞癌（HCC）的发病率在世界各地有所不同，在北欧相对较低（每10万人中少于5例），那里的大多数患者患有肝硬化。在冰岛，HCC的主要危险因素——病毒性肝炎和肝硬化的患病率低于许多其他国家的报告水平。我们研究的目的是调查冰岛HCC的发病率和病因。
纳入1984年至1998年在冰岛诊断为HCC的所有患者。纳入研究需要组织学诊断。通过冰岛癌症登记处以及查阅尸检和组织病理学报告来确定患者。从医疗记录中获取进一步信息。
共识别出71例HCC病例，其中男性51例，女性20例。男性的平均年龄为69.3岁（18 - 95岁），女性为73岁（52 - 89岁）。HCC的年龄标准化年发病率为1.08/10万（男性为2.10，女性为0.67）。在研究期间发病率没有显著增加。酗酒（15.5%）和血色素沉着症（11%）是最常见的危险因素。23例（32%）患有肝硬化，但39例（55%）没有已知的危险因素。在55例有非肿瘤组织可供检查的病例中，27例有肝脏疾病。
1）冰岛HCC的发病率低于其他国家的报告水平。2）酗酒和血色素沉着症是最常见的危险因素。3）肝硬化患者的比例较低。
