Khorsand Aliasghar, Graf Senta, Pirich Christian, Muzik Otto, Kletter Kurt, Dudczak Robert, Maurer Gerald, Sochor Heinz, Schuster Ernst, Porenta Gerold
Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
J Nucl Cardiol. 2005 Jul-Aug;12(4):410-7. doi: 10.1016/j.nuclcard.2005.04.002.
Measurement of myocardial blood flow (MBF) by dynamic nitrogen 13 ammonia (NH(3)) positron emission tomography (PET) uses tracer kinetic modeling to analyze time-activity curves. We compared 2 commonly used models with 2 compartments (2C) and 3 compartments (3C) for quantification of MBF and coronary flow reserve (CFR).
Seventy-seven patients underwent NH(3) PET at rest and during hyperemia. Time-activity curves for blood pool and myocardial segments were obtained from short-axis images of dynamic sequences. Model fitting of the 2C and 3C models was performed to estimate regional MBF. MBF values calculated by 2C and 3C models were 0.98 +/- 0.31 mL.min(-1).g(-1) and 1.11 +/- 0.37 mL.min(-1).g(-1), respectively, at rest (P < .0001) and 2.79 +/- 1.18 mL.min(-1).g(-1) and 2.46 +/- 1.02 mL.min(-1).g(-1), respectively, during hyperemia (P < .01), resulting in a CFR of 3.02 +/- 1.31 and 2.39 +/- 1.15 (P < .0001), respectively. Significant correlation was observed between the 2 models for calculation of resting MBF (r = 0.78), hyperemic MBF (r = 0.68), and CFR (r = 0.68).
Measurements of MBF and CFR by 2C and 3C models are significantly related. However, quantification of MBF and CFR significantly differs between the methods. This difference needs to be considered when normal values are established or when measurements obtained with different methods need to be compared.
通过动态氮 - 13 氨（NH₃）正电子发射断层扫描（PET）测量心肌血流量（MBF）时，使用示踪剂动力学模型来分析时间 - 活性曲线。我们比较了两种常用的两室（2C）和三室（3C）模型用于定量 MBF 和冠状动脉血流储备（CFR）。
77 例患者在静息和充血状态下接受了 NH₃ PET 检查。从动态序列的短轴图像中获取血池和心肌节段的时间 - 活性曲线。进行 2C 和 3C 模型的模型拟合以估计局部 MBF。2C 和 3C 模型计算的静息 MBF 值分别为 0.98±0.31 mL·min⁻¹·g⁻¹ 和 1.11±0.37 mL·min⁻¹·g⁻¹（P <.0001），充血时分别为 2.79±1.18 mL·min⁻¹·g⁻¹ 和 2.46±1.02 mL·min⁻¹·g⁻¹（P <.01），导致 CFR 分别为 3.02±1.31 和 2.39±1.15（P <.0001）。两种模型计算静息 MBF（r = 0.78）、充血 MBF（r = 0.68）和 CFR（r = 0.68）之间观察到显著相关性。
2C 和 3C 模型测量的 MBF 和 CFR 显著相关。然而，两种方法对 MBF 和 CFR 的定量存在显著差异。在建立正常值或比较不同方法获得的测量值时，需要考虑这种差异。
