Bos H J, Schetters T
Intervet International B.V., Boxmeer.
Tijdschr Diergeneeskd. 1990 Dec 1;115(23):1102-10.
Vaccines against gastro-intestinal helminths have a large market potential, but they also generally have a narrow range of activity. This is a major drawback in the competition with the broad-spectrum anthelmintics and there is still a long way to go before molecular (recombinant) vaccines will appear on the market. Major problems are the induction of protective gut-mucosal immunity with subunit vaccines and the differences in genetic background within host populations, which largely determine the efficacy of vaccination. As yet the changes for vaccines against blood- and tissue parasites, comprising a number of veterinary important protozoa, seem to be better.
针对胃肠道蠕虫的疫苗具有巨大的市场潜力，但它们的活性范围通常较窄。这在与广谱驱虫药的竞争中是一个主要缺点，而且在分子（重组）疫苗上市之前仍有很长的路要走。主要问题是亚单位疫苗诱导保护性肠道黏膜免疫的能力以及宿主群体内遗传背景的差异，这在很大程度上决定了疫苗接种的效果。迄今为止，针对包括一些对兽医来说很重要的原生动物在内的血液和组织寄生虫的疫苗的前景似乎更好。
