Tsujimoto Hironori, Ono Satoshi, Chochi Kentaro, Sugasawa Hidekazu, Ichikura Takashi, Mochizuki Hidetaka
Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
Jpn J Clin Oncol. 2006 Oct;36(10):632-7. doi: 10.1093/jjco/hyl096. Epub 2006 Oct 4.
Chemoradiotherapy (CRT) has been established to improve the long-term survival in patients with esophageal carcinoma. However, little is known about whether preoperative CRT may affect the postoperative systemic response.
We investigated the postoperative clinical course in terms of the systemic inflammatory response syndrome (SIRS) in patients with preoperative CRT (CRT group) and surgery alone (SA group).
Both the postoperative heart and respiratory rate in the CRT group were significantly higher than in the SA group. The duration and incidence of SIRS, as well as the number of positive criteria for SIRS, were significantly greater than those in the SA group. There was no difference in the postoperative morbidity and mortality between the two groups.
Preoperative CRT was found to significantly enhance the postoperative SIRS, thus suggesting its potentially higher risk of complications.
放化疗（CRT）已被证实可提高食管癌患者的长期生存率。然而，关于术前放化疗是否会影响术后全身反应，人们知之甚少。
我们根据全身炎症反应综合征（SIRS）调查了术前接受放化疗的患者（CRT组）和单纯接受手术的患者（SA组）的术后临床病程。
CRT组术后心率和呼吸频率均显著高于SA组。SIRS的持续时间和发生率，以及SIRS阳性标准的数量，均显著高于SA组。两组术后发病率和死亡率无差异。
发现术前放化疗可显著增强术后SIRS，提示其并发症风险可能更高。
