Bertolaccini Maria Laura, Mepani Kirti, Sanna Giovanni, Hughes Graham R V, Khamashta Munther A
Lupus Research Unit, The Rayne Institute, King's College London School of Medicine at Guy's, King's and St Thomas' Hospitals, London SE1 7EH, UK.
Ann Rheum Dis. 2007 Apr;66(4):533-6. doi: 10.1136/ard.2006.059022. Epub 2006 Oct 4.
To investigate the clinical significance of anti-factor XII (FXII) in a large cohort of patients with systemic lupus erythematosus (SLE).
This study comprised 127 patients with SLE. IgG and IgM anti-FXII were tested by an in-house ELISA. 123 healthy donors comprised the control group.
51 (40%) patients with SLE and 9 (7%) healthy controls were positive for anti-FXII. IgG and IgM anti-FXII were frequently found in patients with thrombosis (28% and 13%, respectively). Levels of IgG and IgM anti-FXII were higher in patients with thrombosis than in the control group (p<0.001 and p=0.005, respectively). Anti-FXII was more frequent in patients with arterial thrombosis (31% vs 4% for IgG and 14% vs 3% for IgM, respectively) and venous thrombosis than in controls (37% vs 4% for IgG). IgG anti-FXII were more frequent in patients with miscarriages and fetal death (35% and 40% vs 4% for IgM). The prevalence of IgM anti-FXII was not different between groups.
Anti-FXII are frequent in patients with SLE. Their presence is associated with thrombosis and adverse obstetric history, making these antibodies a novel marker for the antiphospholipid syndrome.
在一大群系统性红斑狼疮（SLE）患者中研究抗凝血因子 XII（FXII）的临床意义。
本研究纳入了127例SLE患者。采用自制酶联免疫吸附测定法（ELISA）检测IgG和IgM抗FXII。123名健康献血者作为对照组。
51例（40%）SLE患者和9例（7%）健康对照者抗FXII呈阳性。血栓形成患者中IgG和IgM抗FXII的检出率较高（分别为28%和13%）。血栓形成患者的IgG和IgM抗FXII水平高于对照组（分别为p<0.001和p=0.005）。动脉血栓形成患者（IgG分别为31%对4%，IgM分别为14%对3%）和静脉血栓形成患者中抗FXII的检出率高于对照组（IgG为37%对4%）。流产和胎儿死亡患者中IgG抗FXII更为常见（分别为35%和40%，而IgM为4%）。各组间IgM抗FXII的患病率无差异。
SLE患者中抗FXII较为常见。其存在与血栓形成及不良产科病史相关，使这些抗体成为抗磷脂综合征的一种新标志物。
