207例系统性红斑狼疮患者的抗人凝血酶原自身抗体及临床表现
Autoantibodies to human prothrombin and clinical manifestations in 207 patients with systemic lupus erythematosus.
作者信息
Bertolaccini M L, Atsumi T, Khamashta M A, Amengual O, Hughes G R
机构信息
Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, London, UK.
出版信息
J Rheumatol. 1998 Jun;25(6):1104-8.
OBJECTIVE
Prothrombin (factor II) is one of the phospholipid binding proteins with a procoagulant property. Some publications have shown the presence of autoantibodies against prothrombin (aPT) in patients with antiphospholipid antibodies (aPL). We assessed the clinical significance of aPT in thrombotic events in patients with systemic lupus erythematosus (SLE).
METHODS
IgG and IgM aPT were tested by ELISA in 207 patients with SLE.
RESULTS
Fifty-eight patients (28%) had positive aPT (> mean + 3 SD of 100 controls). Twenty-eight (14%) had IgG alone, 21 (10%) IgM alone, and 9 (4%) had both IgG and IgM. Patients with aPT had a history of thrombosis more frequently than those without aPT [31/58 (53%) vs 47/149 (32%), chi-squared=7.6, p=0.006]. No correlation was found between the presence of aPT and clinical features of SLE.
CONCLUSION
aPT are frequently found in patients with SLE, and are a potential marker for thrombosis.
目的
凝血酶原（因子II）是一种具有促凝特性的磷脂结合蛋白。一些出版物表明抗磷脂抗体（aPL）患者体内存在抗凝血酶原自身抗体（aPT）。我们评估了aPT在系统性红斑狼疮（SLE）患者血栓形成事件中的临床意义。
方法
采用酶联免疫吸附测定法（ELISA）检测207例SLE患者的IgG和IgM aPT。
结果
58例患者（28%）aPT呈阳性（>100名对照者的平均值+3标准差）。28例（14%）仅IgG呈阳性，21例（10%）仅IgM呈阳性，9例（4%）IgG和IgM均呈阳性。aPT阳性患者发生血栓形成的病史比aPT阴性患者更常见[31/58（53%）对47/149（32%），卡方检验=7.6，p=0.006]。未发现aPT的存在与SLE的临床特征之间存在相关性。
结论
aPT在SLE患者中经常出现，是血栓形成的一个潜在标志物。
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