异二聚体病毒粒子的前病毒后代显示出人类免疫缺陷病毒2型的高交叉率。
Proviral progeny of heterodimeric virions reveal a high crossover rate for human immunodeficiency virus type 2.
作者信息
Mukherjee Sayandip, Lee Hui-Ling Rose, Ron Yacov, Dougherty Joseph P
机构信息
Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA.
出版信息
J Virol. 2006 Dec;80(24):12402-7. doi: 10.1128/JVI.01709-06. Epub 2006 Oct 4.
Abstract
Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS in humans, exhibits a very high rate of recombination. Bearing in mind the significant epidemiological and clinical contrast between HIV-2 and HIV-1 as well as the critical role that recombination plays in viral evolution, we examined the nature of HIV-2 recombination. Towards this end, a strategy was devised to measure the rate of crossover of HIV-2 by evaluating recombinant progeny produced exclusively by heterodimeric virions. The results showed that HIV-2 exhibits a crossover rate similar to that of HIV-1 and murine leukemia virus, indicating that the extremely high rate of crossover is a common retroviral feature.
摘要
人类免疫缺陷病毒1型（HIV-1）是人类艾滋病的病原体，其重组率非常高。鉴于HIV-2和HIV-1在流行病学和临床方面存在显著差异，以及重组在病毒进化中所起的关键作用，我们研究了HIV-2重组的本质。为此，我们设计了一种策略，通过评估仅由异二聚体病毒体产生的重组子代来测量HIV-2的交叉率。结果表明，HIV-2的交叉率与HIV-1和鼠白血病病毒相似，这表明极高的交叉率是逆转录病毒的共同特征。
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