Deguchi K
Jpn J Antibiot. 1977 May;30(5):315-20.
(1) The antibacterial acivity of ciclacillin (ACPC) with inoculum size of 10(6) cells/ml was four times less potent than that of ampicillin (ABPC) and 4 approximately 8 times less potent than that of AMPC, but was 4 approximately 8 times more potent than that of CEX against Streptococcus pyogenes. For Streptococcus pneumoniae, ACPC was 2 approximately 4 times less active than ABPC and AMPC, but 16 approximately 32 times more active than CEX. Staphylococcus aureus was 4 approximately 8 times less susceptible to ACPC than to ABPC and AMPC, but 1 approximately 2 times more susceptible than to CEX. Against E. coli, ACPC was as active as CEX, 2 approximately 4 times less active than ABPC, and 4 approximately 8 times less active than AMPC. (2) It was suposed that ACPC was more resistant to penicillinase and more antibacterial with inoculum size of 10(6) cells/ml cells/ml than with 10(6) cells/ml. ACPC was 4 approximately 8 times less active than ABPC, and AMPC against Staphylococcus aureus with 10(8) cells/ml, while with 10(6) cells/ml, it was 2 times less active than ABPC and AMPC. (3) ACPC-resistant strains (greater than or equal to 3.13 microng/ml) of Streptococcus pyogenes and Streptococcus pneumoniae were not found. (4) A difference was noted in MIC of three semi-synthetic penicillins, ACPC, ABPC and AMPC, against Staphylococcus aureus, and E. coli between the sources from which their strains were isolated. (5) There were many strains resistant to erythromycin (EM) and josamycin (JM) (greater than 60%, respectively to both antibiotics) in Stretpococcus pyogenes and pus-isolated Staphylococcus aureus. No strains of Streptococcus pyogenes, were found resistant to EM and JM.
(1) 环青霉素（ACPC）对每毫升含10⁶个细胞接种量的抗菌活性比氨苄西林（ABPC）低四倍，比氨氯青霉素（AMPC）低约4至8倍，但对化脓性链球菌的抗菌活性比头孢氨苄（CEX）高约4至8倍。对于肺炎链球菌，ACPC的活性比ABPC和AMPC低约2至4倍，但比CEX高16至32倍。金黄色葡萄球菌对ACPC的敏感性比ABPC和AMPC低约4至8倍，但比CEX高约1至2倍。对大肠杆菌而言，ACPC的活性与CEX相当，比ABPC低约2至4倍，比AMPC低约4至8倍。(2) 据推测，ACPC对青霉素酶的抗性更强，且每毫升含10⁶个细胞接种量时的抗菌活性比每毫升含10⁸个细胞时更高。ACPC对每毫升含10⁸个细胞的金黄色葡萄球菌的活性比ABPC和AMPC低约4至8倍，而每毫升含10⁶个细胞时，其活性比ABPC和AMPC低2倍。(3) 未发现化脓性链球菌和肺炎链球菌的ACPC耐药菌株（大于或等于3.13微克/毫升）。(4) 注意到三种半合成青霉素ACPC、ABPC和AMPC对金黄色葡萄球菌和大肠杆菌的最低抑菌浓度（MIC）因菌株分离来源不同而存在差异。(5) 在化脓性链球菌和脓性分泌物分离出的金黄色葡萄球菌中，有许多菌株对红霉素（EM）和交沙霉素（JM）耐药（分别对两种抗生素的耐药率均大于60%）。未发现化脓性链球菌对EM和JM耐药的菌株。
