引起泌尿系统感染的细菌对三种药物（阿莫西林、氨苄西林和头孢氨苄）的敏感性及阿莫西林的临床疗效（作者译）
[Sensitivity of bacteria inducing urinary infections to 3 drugs (amoxicillin, ampicillin and cephalexin) and clinical efficacy of amoxicillin (author's transl)].
作者信息
Fukushima S, Fujii H, Kitajima N, Suzuki M
出版信息
Jpn J Antibiot. 1975 Dec;28(6):795-801.
MIC of amoxicillin (AMPC), ampicillin (ABPC) and cephalexin (CEX) against bacteria detected from the patients suffering from urinary infections was determined and the clinical efficacy of AMPC was examined. As the result of determining MIC of AMPC against the detected Escherichia coli, 85.4% showed the value of less than 6.25 mcg/ml. AMPC and ABPC seem to be well correlated with each other regarding MIC, and AMPC showed 1 approximately to 2 stage lower concentration than CEX. In connection to clinical efficacy of AMPC, the oral administration at a daily dose of 750 mg gave the effectiveness rate of 92.5%. Few side effects were caused by administering AMPC and this is an excellent drug for healing acute simple urinary infections.
测定了阿莫西林（AMPC）、氨苄西林（ABPC）和头孢氨苄（CEX）对尿路感染患者所检测出细菌的最低抑菌浓度（MIC），并考察了AMPC的临床疗效。作为测定AMPC对所检测出的大肠杆菌的MIC的结果，85.4%的菌株显示其值低于6.25 mcg/ml。AMPC和ABPC在MIC方面似乎彼此具有良好的相关性，并且AMPC显示出比CEX低约1至2个浓度级别。关于AMPC的临床疗效，每日剂量750 mg口服给药的有效率为92.5%。服用AMPC引起的副作用很少，这是治疗急性单纯性尿路感染的一种优良药物。
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