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评估恶性疟原虫和间日疟原虫醛缩酶基因的遗传多样性及其对醛缩酶检测快速诊断试验性能的潜在影响。

Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detecting rapid diagnostic tests.

作者信息

Lee Nelson, Baker Joanne, Bell David, McCarthy James, Cheng Qin

机构信息

The Australian Centre for International and Tropical Health, Brisbane, Australia.

出版信息

J Clin Microbiol. 2006 Dec;44(12):4547-9. doi: 10.1128/JCM.01611-06. Epub 2006 Oct 4.

DOI:10.1128/JCM.01611-06
PMID:17021060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698405/
Abstract

Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.

摘要

针对醛缩酶的疟疾特异性快速诊断测试（RDTs）显示出高度可变的敏感性。我们通过对来自不同来源寄生虫的编码基因进行测序，评估了恶性疟原虫和间日疟原虫醛缩酶的多样性。结果表明，醛缩酶高度保守，这表明抗原多样性不是RDT敏感性变化的原因。

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2
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