Pavlic Marion, Libiseller Kathrin, Grubwieser Petra, Schubert Heinrich, Rabl Walter
Institute of Legal Medicine, Innsbruck Medical University, Innsbruck, Austria.
Int J Legal Med. 2007 May;121(3):169-74. doi: 10.1007/s00414-006-0118-6. Epub 2006 Oct 5.
The benzodiazepine tetrazepam is primarily muscle relaxant with comparably lower central sedating effects and is therefore commonly prescribed for muscle spasms of different origins. To evaluate tetrazepam metabolism, a study was conducted with ten healthy volunteers. Blood and urine samples were regularly collected after the intake of 50 mg tetrazepam. Toxicological analyses revealed that tetrazepam is also metabolized to diazepam and further to nordazepam, which has not yet been reported. Tetrazepam and diazepam could be detected in urine samples at least 72 h after intake, the diazepam concentration being 33% (+/-14% SD), on average, of the tetrazepam concentration. On the basis of three case histories, the importance of the detection of these newly described metabolites is shown as necessary to prevent false accusations and potential negative legal consequences for examined persons.
苯二氮䓬类药物四氢西泮主要是一种肌肉松弛剂，其中枢镇静作用相对较低，因此常用于治疗各种原因引起的肌肉痉挛。为评估四氢西泮的代谢情况，对10名健康志愿者进行了一项研究。在摄入50毫克四氢西泮后定期采集血液和尿液样本。毒理学分析显示，四氢西泮还会代谢为地西泮，并进一步代谢为去甲地西泮，这一点此前尚未见报道。摄入四氢西泮至少72小时后，在尿液样本中仍可检测到四氢西泮和地西泮，地西泮浓度平均为四氢西泮浓度的33%（±14%标准差）。基于三个病例记录，表明检测这些新发现的代谢物对于防止错误指控以及避免给受检者带来潜在的负面法律后果具有必要性。
