Department of Forensic Toxicology, Institute of Forensic Sciences, Ministry of Justice, Shanghai Key Laboratory of Forensic Medicine, Guangfu Xi Road 1347, Shanghai, China.
Int J Legal Med. 2011 Nov;125(6):831-40. doi: 10.1007/s00414-010-0534-5. Epub 2010 Dec 9.
As a rapid-acting dissociative anesthetic, ketamine has been used in drug-facilitated crimes. The aim of this study is to investigate the disposition of ketamine and its main metabolite norketamine in hair after a single dose of ketamine. Four healthy volunteers were recruited into the study. Hair was collected 1, 2, 3, 4, 8, 12 and 16 weeks after a single oral dose of ketamine solution (10 mg) and analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry. The wet cotton swab wiped the scalp of the subjects at 1 h, 24 h, 48 h and 1 week after administration. Maximum hair concentrations (C (max)) for ketamine and norketamine were 19.0 ± 6.5 and 18.7 ± 13.3 pg/mg, respectively. Except for the first week, the ratio of ketamine to norketamine in most of segments (87.5%) was greater than 1. All the cotton swab samples collected at 24 and 48 h were positive. The results from cotton swabs and the concentrations of ketamine and norketamine in hair segments collected at different times showed that some of ketamine and norketamine incorporated into hair originated from sweat and sebum on the scalp of the subjects.
作为一种快速作用的分离麻醉剂，氯胺酮已被用于药物辅助犯罪。本研究旨在探讨单次口服氯胺酮溶液（10mg）后，氯胺酮及其主要代谢物去甲氯胺酮在毛发中的分布情况。招募了 4 名健康志愿者参与该研究。在单次口服氯胺酮溶液（10mg）后 1、2、3、4、8、12 和 16 周，通过液相色谱/电喷雾串联质谱法分析毛发。给药后 1 小时、24 小时、48 小时和 1 周，用湿棉签擦拭受试者头皮。氯胺酮和去甲氯胺酮的最大毛发浓度（Cmax）分别为 19.0±6.5 和 18.7±13.3pg/mg。除第一周外，大多数部位（87.5%）的氯胺酮与去甲氯胺酮比值大于 1。所有在 24 小时和 48 小时采集的棉签样本均为阳性。棉签样本和不同时间采集的毛发段中氯胺酮和去甲氯胺酮的浓度表明，一些进入毛发的氯胺酮和去甲氯胺酮来源于受试者头皮上的汗液和皮脂。
