来自长序金粟兰根的生物活性萜类化合物。

Bioactive terpenes from the roots of Chloranthus henryi.

作者信息

Wu Bin, He Shan, Wu Xiao-Dan, Pan Yuan-Jiang

机构信息

Department of Chemistry, Zhejiang University, Hangzhou, PR China.

出版信息

Planta Med. 2006 Nov;72(14):1334-8. doi: 10.1055/s-2006-947256. Epub 2006 Oct 4.

DOI:10.1055/s-2006-947256

PMID:17022005

Abstract

12,15-Epoxy-5alpha H,9beta H-labda-8(17),13-dien-19-oic acid (1) and 14-methoxy-15,16-dinor-5alpha H,9alpha H-labda-13(E),8(17)-dien-12-one (2), two new labdane-type diterpenes, and 1alpha-hydroxy-8,12-epoxyeudesma-4,7,11-triene-6,9-dione (3), one new eudesmane-type sesquiterpene, were isolated from Chloranthus henryi Hemsl, along with two known compounds, 8beta H-eudesma-4(14),7(11)-dien-12,8-olide (4) and 8beta-hydroxyeudesma-4(14),7(11)-dien-12,8-olide (5). Their structures were established by a combination of 1D- and 2D-NMR spectroscopic techniques. The new compounds 2, 3 and the known compound 4 exhibited antitumor activities against Hela and K562 human tumor cell lines.

摘要

从宽叶金粟兰中分离得到了两种新的半日花烷型二萜，12,15 - 环氧 - 5αH,9βH - 拉布达 - 8(17),13 - 二烯 - 19 - 酸（1）和14 - 甲氧基 - 15,16 - 去甲 - 5αH,9αH - 拉布达 - 13(E),8(17) - 二烯 - 12 - 酮（2），以及一种新的桉叶烷型倍半萜，1α - 羟基 - 8,12 - 环氧桉叶 - 4,7,11 - 三烯 - 6,9 - 二酮（3），同时还得到了两种已知化合物，8βH - 桉叶 - 4(14),7(11) - 二烯 - 12,8 - 内酯（4）和8β - 羟基桉叶 - 4(14),7(11) - 二烯 - 12,8 - 内酯（5）。它们的结构通过一维和二维核磁共振光谱技术确定。新化合物2、3以及已知化合物4对Hela和K562人肿瘤细胞系具有抗肿瘤活性。