安徽金粟兰中的倍半萜和二萜。

Sesquiterpenoids and diterpenoids from Chloranthus anhuiensis.

机构信息

State Key Laboratory of Drug Research & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P R China.

出版信息

Chem Biodivers. 2010 Jan;7(1):151-7. doi: 10.1002/cbdv.200800300.

DOI:10.1002/cbdv.200800300

PMID:20087981

Abstract

A phytochemical investigation of the roots of Chloranthus anhuiensis afforded three new sesquiterpene lactones, chloraniolide A (1), (3R)-3-hydroxyatractylenolide III (2), and 8beta-hydroxy-1-oxoeudesma-3,7(11)-dien-12,8alpha-olide (3), and two new diterpenoids, (12R,13E)-15-(acetoxy)-12-hydroxylabda-8(20),13-dien-19-oic acid (4) and (12S,13E)-15-(acetoxy)-12-dihydroxylabda-8(20),13-dien-19-oic acid (5), as well as 17 known sesquiterpenoid and diterpenoid compounds. Their structures were established on the basis of 1D- and 2D-NMR, and other spectroscopic analyses.

摘要

对安徽金粟兰根的化学成分研究得到了三种新的倍半萜内酯，即chloraniolide A（1）、（3R）-3-羟基莪术呋喃酮 III（2）和 8β-羟基-1-氧代桉叶-3,7(11)-二烯-12,8α-内酯（3），以及两种新的二萜，（12R,13E）-15-（乙酰氧基）-12-羟基-12-亚麻酸-8(20),13-二烯-19-酸（4）和（12S,13E）-15-（乙酰氧基）-12-二羟基-12-亚麻酸-8(20),13-二烯-19-酸（5），以及 17 种已知的倍半萜和二萜化合物。它们的结构是基于 1D 和 2D-NMR 以及其他光谱分析确定的。