Diego Raúl Brígido, Estellés Jorge Más, Sanz José Antonio, García-Aznar José Manuel, Sánchez Manuel Salmerón
Center for Biomaterials, Universidad Politécnica de Valencia, 46022 Valencia, Spain.
J Biomed Mater Res B Appl Biomater. 2007 May;81(2):448-55. doi: 10.1002/jbm.b.30683.
A method is proposed in which the geometric properties of 3D scaffolds with application in tissue engineering can be tailored: porosity, pore size, and interconnection throat size. The architecture of the fabricated scaffolds is analyzed by scanning electron microscopy. The mechanical properties of these structures are discussed on the basis of compression stress-strain measurements. Moreover, the mechanical properties of the scaffolds are estimated by means of finite element modeling (FEM) in which the compression stress-strain test is simulated on an ideal structure based on the crystalline face centered cubic system. The elastic properties of the constructs are explained on the basis of the FEM model that supports the main mechanical conclusion of the experimental results: the compressive modulus in the first linear region does not depend on the geometric characteristics of the pore (pore size, interconnection throat size) but only on the total porosity of the scaffold.
提出了一种方法，通过该方法可以调整用于组织工程的3D支架的几何特性：孔隙率、孔径和连通喉道尺寸。通过扫描电子显微镜分析所制备支架的结构。基于压缩应力-应变测量结果讨论了这些结构的力学性能。此外，借助有限元建模（FEM）估算支架的力学性能，其中基于晶面心立方体系在理想结构上模拟压缩应力-应变试验。基于FEM模型解释了构建体的弹性特性，该模型支持实验结果的主要力学结论：第一线性区域的压缩模量不取决于孔隙的几何特征（孔径、连通喉道尺寸），而仅取决于支架的总孔隙率。
