Gerhardt Lutz-Christian, Boccaccini Aldo R
Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK.
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.
Materials (Basel). 2010 Jul 6;3(7):3867-3910. doi: 10.3390/ma3073867.
Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.
传统上，生物活性玻璃一直用于填充和修复骨缺损。最近，这类生物材料已成为骨组织工程应用的一个新兴研究领域。在此，我们基于熔融衍生的生物活性硅酸盐玻璃成分及相关复合结构，对多孔骨组织工程支架的现有知识进行综述和讨论。首先摘录生物活性玻璃的历史以及骨组织工程支架的基本要求，接着将详细概述生物活性玻璃和玻璃陶瓷支架的最新进展，包括常用制备方法的总结以及关于支架与人体骨骼相关的微观结构 - 力学性能的讨论（结构 - 性能和结构 - 功能关系）。此外，还将探讨生物活性玻璃在成骨和血管生成反应方面的离子释放效应。最后，本综述将突出未来的研究领域。
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