Dikshith T S, Srivastava M K, Raizada R B
Industrial Toxicology Research Centre, Mahatama Gandhi Marg, Lucknow, India.
Vet Hum Toxicol. 1990 Dec;32(6):524-7.
Administration of single po doses of technical hexachlorocyclohexane (HCH) (5, 25, 50, 100 or 200 mg/kg) to mice on day 9 of gestation caused dose-related toxic effects in the fetuses. HCH-treated dams had consistent decreases. The percent resorption and the number of live fetuses/dam indicated that high concentrations of HCH trigger fetotoxic effects. Enzymatic changes in the livers of control and HCH-treated groups showed significant alterations. Accumulation of HCH was in the fatty tissue, brain, liver and blood.
在妊娠第9天给小鼠单次口服技术级六氯环己烷（HCH）（5、25、50、100或200毫克/千克）会对胎儿产生剂量相关的毒性作用。经HCH处理的母鼠出现持续下降。吸收百分比和每只母鼠的活胎数量表明，高浓度的HCH会引发胎儿毒性作用。对照组和经HCH处理组小鼠肝脏中的酶变化显示出显著改变。HCH在脂肪组织、脑、肝脏和血液中蓄积。
