Srivastava M K, Raizada R B
Pesticide Toxicology Laboratory, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
J Toxicol Environ Health. 1993 Sep;40(1):105-15. doi: 10.1080/15287399309531778.
Technical hexachlorocyclohexane (5, 25, and 50 mg/kg/d) was orally administered to mice during the pre- and postimplantation period. While mice exposed to HCH during the preimplantation period did not show fetolethality, exposure during the postimplantation period showed dose-dependent effects on fetuses as evidenced by increase in percentage resorption, higher level of HCH residue, and decreased serum progesterone level. The absence of anomalies in fetal gross morphology and skeleton suggests technical HCH is nonteratogenic in mice.
在植入前和植入后阶段，给小鼠口服工业用六氯环己烷（剂量分别为5、25和50毫克/千克/天）。虽然在植入前阶段接触六氯环己烷的小鼠未出现胚胎致死情况，但植入后阶段的接触对胎儿显示出剂量依赖性影响，表现为吸收百分比增加、六氯环己烷残留水平升高以及血清孕酮水平降低。胎儿大体形态和骨骼未出现异常表明工业用六氯环己烷对小鼠无致畸性。
