Gerhard I, Daniel V, Link S, Monga B, Runnebaum B
Department of Gynecological Endocrinology and Reproduction, Women's Hospital, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany.
Environ Health Perspect. 1998 Oct;106(10):675-81. doi: 10.1289/ehp.98106675.
This study was conducted to investigate a possible etiological role of chlorinated hydrocarbons in the pathogenesis of repeated miscarriages. The blood levels of chlorinated hydrocarbons [CHCs: pentachlorophenol, hexachlorocyclohexane, hexachlorobenzene, the dichlorodiphenyltrichloroethane (DDT) group, polychlorinated biphenyls] were determined in 89 women with repeated miscarriages, who were referred to the University Hospital of Obstetrics and Gynecology of Heidelberg for investigations between 1989 and 1993, and compared to a previously investigated reference population. In more than 20% of the women, at least one of the CHC levels exceeded the reference range. CHC levels did not differ significantly between women with primary or secondary and early or late miscarriages; neither did they differ between women with hormonal or immunological disorders as causes of repeated miscarriages or women with idiopathic repeated miscarriages. No significant associations were detected between CHC levels and further conceptions or the outcome of further pregnancies. As significant associations were found between increasing CHC blood concentrations and immunological and hormonal changes, CHCs may have an impact on the pregnancy course in certain cases.
本研究旨在调查氯代烃在反复流产发病机制中可能的病因学作用。对1989年至1993年间转诊至海德堡大学妇产科医院进行检查的89例反复流产妇女的血液中氯代烃（CHCs：五氯苯酚、六氯环己烷、六氯苯、二氯二苯三氯乙烷（DDT）类、多氯联苯）水平进行了测定，并与之前调查的参考人群进行了比较。超过20%的妇女中，至少有一种CHC水平超出参考范围。原发性或继发性、早期或晚期流产的妇女之间CHC水平无显著差异；因激素或免疫紊乱导致反复流产的妇女与特发性反复流产的妇女之间CHC水平也无差异。未发现CHC水平与再次受孕或后续妊娠结局之间存在显著关联。由于发现CHC血液浓度升高与免疫和激素变化之间存在显著关联，因此在某些情况下，CHCs可能会对妊娠过程产生影响。
