Odaka T
Int J Cancer. 1975 Oct 15;16(4):622-8. doi: 10.1002/ijc.2910160412.
The effects of two chemical carcinogens, nitrosobutylurea and 7,12-dimethylbenz-(a) anthracene, on the expression of endogenous N- and B-tropic viruses were studied. The mice used were from two inbred strains, C57BL/6 and DDD-Fvr, and from 13 partially inbred strains derived from the cross of C57BL/6 with DDD-Ffr. These mouse strains are classified into three groups by the pattern of expression of endogenous viruses in normal, aged mice: (1) negative for both viruses; (2) positive for N-tropic virus only; and (3) positive for both viruses. Mice were given the carcinogens, and were tested at various intervals by the UV-XC procedure for the viruses in the spleens and other enlarged organs. Irrespective of the presence or absence of leukemias, the carcinogen-treated mice showed the same pattern of expression of endogenous viruses as that of non-treated normal mice. It can be concluded that the activation of the endogenous viruses is dependent on the mouse strains and that the growth of the activated viruses is not a necessary step for the chemical induction of leukemias.
研究了两种化学致癌物，亚硝基丁脲和7,12-二甲基苯并(a)蒽，对内源性N型和B型嗜性病毒表达的影响。所用小鼠来自两个近交系，C57BL/6和DDD-Fvr，以及13个由C57BL/6与DDD-Ffr杂交产生的部分近交系。这些小鼠品系根据正常老龄小鼠内源性病毒的表达模式分为三组：(1)两种病毒均为阴性；(2)仅N型嗜性病毒为阳性；(3)两种病毒均为阳性。给小鼠施用致癌物，并通过UV-XC程序在不同时间间隔对脾脏和其他肿大器官中的病毒进行检测。无论是否存在白血病，经致癌物处理的小鼠内源性病毒的表达模式与未处理的正常小鼠相同。可以得出结论，内源性病毒的激活取决于小鼠品系，并且激活病毒的生长不是化学诱导白血病的必要步骤。
