Colla Michael, Kronenberg Golo, Deuschle Michael, Meichel Kornelia, Hagen Thomas, Bohrer Markus, Heuser Isabella
Department of Psychiatry, Charité, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany.
J Psychiatr Res. 2007 Oct;41(7):553-60. doi: 10.1016/j.jpsychires.2006.06.011. Epub 2006 Oct 4.
Structural imaging studies investigating hippocampal volumes in patients suffering from major depression have yielded mixed results. Here, 24 unipolar depressed in-patients and 14 healthy controls carefully matched for age, gender, and years of education underwent quantitative magnetic resonance imaging (MRI). Saliva cortisol was measured at 0800 and 1600 h in patients during a one-week wash-out and the following 4 weeks. Hippocampal volumes were significantly reduced in the patient group even after adjusting for intracranial brain volume (ICV) and age. Across groups, age was significantly negatively correlated with uncorrected hippocampal volumes. In patients, severity of disease (baseline HAMD scores) and baseline cortisol levels were not related to hippocampal volumes. However, there was a negative association between duration of the index episode before hospitalization and hippocampal volumes. Additionally, hippocampal volumes were significantly negatively correlated with duration of illness. Finally, we observed a trend for higher hippocampal volumes in those patients who showed a subsequent decrease in cortisol levels under pharmacotherapy.
针对重度抑郁症患者海马体体积的结构成像研究结果不一。在此，24名单相抑郁症住院患者和14名在年龄、性别和受教育年限方面仔细匹配的健康对照者接受了定量磁共振成像（MRI）检查。在为期一周的洗脱期及随后的4周内，于08:00和16:00测量患者的唾液皮质醇。即使在校正颅内脑容量（ICV）和年龄后，患者组的海马体体积仍显著减小。在所有组中，年龄与未校正的海马体体积显著负相关。在患者中，疾病严重程度（基线汉密尔顿抑郁量表评分）和基线皮质醇水平与海马体体积无关。然而，住院前指数发作的持续时间与海马体体积呈负相关。此外，海马体体积与病程显著负相关。最后，我们观察到，在药物治疗下皮质醇水平随后下降的患者中，海马体体积有升高的趋势。
