MacQueen Glenda M, Campbell Stephanie, McEwen Bruce S, Macdonald Kathryn, Amano Shigeko, Joffe Russell T, Nahmias Claude, Young L Trevor
Mood Disorders Program, Department of Radiology, McMaster University, Hamilton, ON, Canada L8N 3Z5.
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1387-92. doi: 10.1073/pnas.0337481100. Epub 2003 Jan 24.
Studies have examined hippocampal function and volume in depressed subjects, but none have systematically compared never-treated first-episode patients with those who have had multiple episodes. We sought to compare hippocampal function, as assessed by performance on hippocampal-dependent recollection memory tests, and hippocampal volumes, as measured in a 1.5-T magnetic resonance imager, in depressed subjects experiencing a postpubertal onset of depression. Twenty never-treated depressed subjects in a first episode of depression were compared with matched healthy control subjects. Seventeen depressed subjects with multiple past episodes of depression were also compared with matched healthy controls and to the first-episode patients. Both first- and multiple-episode depressed groups had hippocampal dysfunction apparent on several tests of recollection memory; only depressed subjects with multiple depressive episodes had hippocampal volume reductions. Curve-fitting analysis revealed a significant logarithmic association between illness duration and hippocampal volume. Reductions in hippocampal volume may not antedate illness onset, but volume may decrease at the greatest rate in the early years after illness onset.
已有研究对抑郁症患者的海马体功能和体积进行了检测，但尚无研究系统地比较未经治疗的首发患者与有多次发作史的患者。我们试图比较青春期后起病的抑郁症患者的海马体功能（通过海马体依赖性回忆记忆测试表现进行评估）和海马体体积（通过1.5-T磁共振成像仪测量）。将20名首次发作且未经治疗的抑郁症患者与匹配的健康对照者进行比较。还将17名有多次既往抑郁症发作史的抑郁症患者与匹配的健康对照者以及首发患者进行比较。首发和多次发作的抑郁症组在多项回忆记忆测试中均表现出海马体功能障碍；只有有多次抑郁发作史的抑郁症患者海马体体积减小。曲线拟合分析显示病程与海马体体积之间存在显著的对数关联。海马体体积减小可能并非早于疾病 onset，但在疾病 onset后的最初几年体积可能以最大速率下降。 （注：原文中“onset”未明确翻译，可根据上下文理解为“起病”等意思）
