Klein Johannes C, Behrens Timothy E J, Robson Matthew D, Mackay Clare E, Higham Desmond J, Johansen-Berg Heidi
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Neuroimage. 2007 Jan 1;34(1):204-11. doi: 10.1016/j.neuroimage.2006.08.022. Epub 2006 Oct 3.
The identification of specialized, functional regions of the human cortex is a vital precondition for neuroscience and clinical neurosurgery. Functional imaging modalities are used for their delineation in living subjects, but these methods rely on subject cooperation, and many regions of the human brain cannot be activated specifically. Diffusion tractography is a novel tool to identify such areas in the human brain, utilizing underlying white matter pathways to separate regions of differing specialization. We explore the reproducibility, generalizability and validity of diffusion tractography-based localization in four functional areas across subjects, timepoints and scanners, and validate findings against fMRI and post-mortem cytoarchitectonic data. With reproducibility across modalities, clustering methods, scanners, timepoints, and subjects in the order of 80-90%, we conclude that diffusion tractography represents a useful and objective tool for parcellation of the human cortex into functional regions, enabling studies into individual functional anatomy even when there are no specific activation paradigms available.
识别人类大脑皮层的特定功能区域是神经科学和临床神经外科的重要前提条件。功能成像模态用于在活体受试者中描绘这些区域，但这些方法依赖于受试者的配合，而且人类大脑的许多区域无法被特异性激活。扩散张量成像（Diffusion tractography）是一种识别大脑中此类区域的新工具，它利用潜在的白质通路来区分不同功能的区域。我们在跨受试者、时间点和扫描仪的四个功能区域中探索基于扩散张量成像定位的可重复性、普遍性和有效性，并根据功能磁共振成像（fMRI）和死后细胞构筑数据验证研究结果。各模态、聚类方法、扫描仪、时间点和受试者之间的可重复性达到80%-90%，我们得出结论，扩散张量成像代表了一种将人类大脑皮层划分为功能区域的有用且客观的工具，即使在没有特定激活范式的情况下，也能够对个体功能解剖结构进行研究。
