从霍奇金-赫胥黎轴突到虚拟心脏。
From the Hodgkin-Huxley axon to the virtual heart.
作者信息
Noble Denis
机构信息
Department of Physiology, Anatomy and Genetics, Parks Road, Oxford, OX1 3PT, UK.
出版信息
J Physiol. 2007 Apr 1;580(Pt 1):15-22. doi: 10.1113/jphysiol.2006.119370. Epub 2006 Oct 5.
Abstract
Experimentally based models of the heart have been developed since 1960, starting with the discovery and modelling of potassium channels. The early models were based on extensions of the Hodgkin-Huxley nerve impulse equations. The first models including calcium balance and signalling were made in the 1980s and have now reached a high degree of physiological detail. During the 1990s these cell models have been incorporated into anatomically detailed tissue and organ models to create the first virtual organ, the Virtual Heart. With over 40 years of interaction between simulation and experiment, the models are now sufficiently refined to begin to be of use in drug development.
摘要
自1960年以来，基于实验的心脏模型已经得到发展，始于钾通道的发现和建模。早期模型是基于霍奇金-赫胥黎神经冲动方程的扩展。包括钙平衡和信号传导的首批模型是在20世纪80年代制作的，如今已达到高度的生理细节。在20世纪90年代，这些细胞模型已被纳入具有详细解剖结构的组织和器官模型中，以创建首个虚拟器官——虚拟心脏。经过40多年模拟与实验的相互作用，这些模型如今已得到充分完善，开始用于药物研发。
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