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1
B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells.B细胞外在CR1/CR2促进天然抗体产生及抗α-半乳糖产生的B-1细胞的耐受性诱导。
Blood. 2007 Feb 15;109(4):1773-81. doi: 10.1182/blood-2006-02-002386. Epub 2006 Oct 5.
2
Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism.通过非清髓性诱导混合嵌合体使预先致敏的α1,3-半乳糖基转移酶缺陷小鼠中Galα1,3Gal反应性B细胞产生耐受。
Xenotransplantation. 2001 Nov;8(4):227-38. doi: 10.1034/j.1399-3089.2001.00006.x.
3
High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism.高抗原水平并不排除通过混合嵌合体诱导B细胞对α1,3-半乳糖产生耐受性。
Xenotransplantation. 2008 Sep-Oct;15(5):313-20. doi: 10.1111/j.1399-3089.2008.00487.x.
4
Sequential analysis of anti-alpha Gal natural antibody-producing B cells in GalT knockout mice in cyclophosphamide-induced tolerance.环磷酰胺诱导耐受的GalT基因敲除小鼠中抗α半乳糖天然抗体产生B细胞的序列分析
Scand J Immunol. 2006 Jun;63(6):435-43. doi: 10.1111/j.1365-3083.2006.001763.x.
5
Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen.采用非清髓方案的慢病毒基因疗法诱导耐受性
Blood. 2006 Mar 15;107(6):2286-93. doi: 10.1182/blood-2005-03-1172. Epub 2005 Nov 15.
6
Efficacy and limitations of cyclophosphamide-induced tolerance against alphaGal antigen.环磷酰胺诱导的针对αGal抗原的耐受性的功效与局限性
Scand J Immunol. 2005 Sep;62(3):271-80. doi: 10.1111/j.1365-3083.2005.01644.x.
7
Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response.滤泡树突状细胞上补体受体1和2的表达对于产生强烈的抗原特异性IgG反应是必要的。
J Immunol. 1998 Jun 1;160(11):5273-9.
8
T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism.在α1,3-半乳糖基转移酶缺陷小鼠中，通过非清髓性诱导混合嵌合体，可实现T细胞和B细胞对表达α1,3-半乳糖（GALα1,3GAL）的心脏异种移植物的耐受。
Transplantation. 2001 Jun 15;71(11):1532-42. doi: 10.1097/00007890-200106150-00009.
9
Anti-Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction.未修饰狒狒和经诱导耐受预处理狒狒中针对猪骨髓的抗Gal(α)1-3Gal抗体反应。
Transplantation. 1998 Jul 27;66(2):176-82. doi: 10.1097/00007890-199807270-00006.
10
Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1.最佳生发中心 B 细胞激活和 T 细胞依赖性抗体应答需要表达小鼠补体受体 Cr1。
J Immunol. 2013 Jul 1;191(1):434-47. doi: 10.4049/jimmunol.1203176. Epub 2013 Jun 3.

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1
Progress in xenotransplantation: overcoming immune barriers.异种移植的进展：克服免疫障碍。
Nat Rev Nephrol. 2022 Dec;18(12):745-761. doi: 10.1038/s41581-022-00624-6. Epub 2022 Oct 5.
2
Current status of xenotransplantation research and the strategies for preventing xenograft rejection.异种移植研究的现状与防止异种移植物排斥反应的策略。
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3
Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives.嵌合状态诱导的人肾移植免疫耐受：新的见解和未来展望。
Front Immunol. 2022 Jan 5;12:791725. doi: 10.3389/fimmu.2021.791725. eCollection 2021.
4
Mixed xenogeneic porcine chimerism tolerizes human anti-pig natural antibody-producing cells in a humanized mouse model.混合异种嵌合猪嵌合体在人源化小鼠模型中耐受人抗猪天然抗体产生细胞。
Xenotransplantation. 2021 Jul;28(4):e12691. doi: 10.1111/xen.12691. Epub 2021 Apr 26.
5
IXA Honorary Member Lecture, 2017: The long and winding road to tolerance.2017 年 IXA 荣誉会员演讲：通往宽容的漫长曲折之路。
Xenotransplantation. 2018 May;25(3):e12419. doi: 10.1111/xen.12419.
6
Tolerance in xenotransplantation.异种移植中的耐受性
Curr Opin Organ Transplant. 2017 Dec;22(6):522-528. doi: 10.1097/MOT.0000000000000466.
7
Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology.补体调节与肾脏疾病：补体激活在肾脏病学中双刃剑作用的最新认识
Clin Exp Nephrol. 2018 Feb;22(1):3-14. doi: 10.1007/s10157-017-1405-x. Epub 2017 Mar 24.
8
Immunological challenges and therapies in xenotransplantation.异种移植中的免疫挑战与治疗
Cold Spring Harb Perspect Med. 2014 Apr 1;4(4):a015578. doi: 10.1101/cshperspect.a015578.
9
High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism.高抗原水平并不排除通过混合嵌合体诱导B细胞对α1,3-半乳糖产生耐受性。
Xenotransplantation. 2008 Sep-Oct;15(5):313-20. doi: 10.1111/j.1399-3089.2008.00487.x.
10
Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.通过混合造血嵌合体调控免疫系统以实现抗肿瘤反应和移植耐受。
Immunol Rev. 2008 Jun;223:334-60. doi: 10.1111/j.1600-065X.2008.00636.x.

本文引用的文献

1
Differing mechanisms of early and late B cell hyporesponsiveness induced by mixed chimerism.混合嵌合体诱导的早期和晚期B细胞低反应性的不同机制。
Am J Transplant. 2005 Dec;5(12):2821-9. doi: 10.1111/j.1600-6143.2005.01121.x.
2
Association of B-1 B cells with follicular dendritic cells in spleen.脾脏中B-1 B细胞与滤泡树突状细胞的关联。
J Immunol. 2005 Jun 1;174(11):6918-26. doi: 10.4049/jimmunol.174.11.6918.
3
Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1.补体受体调节表达转录因子Blimp-1和XBP-1的骨髓浆细胞前体的分化。
J Exp Med. 2005 Mar 21;201(6):993-1005. doi: 10.1084/jem.20042239. Epub 2005 Mar 14.
4
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.以α1,3-半乳糖基转移酶基因敲除猪作为供体的狒狒心脏移植：初步经验。
Nat Med. 2005 Jan;11(1):29-31. doi: 10.1038/nm1171. Epub 2004 Dec 26.
5
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.通过使用α1,3-半乳糖基转移酶基因敲除供体和移植带血管的胸腺组织，显著延长狒狒体内猪肾异种移植的存活时间。
Nat Med. 2005 Jan;11(1):32-4. doi: 10.1038/nm1172. Epub 2004 Dec 26.
6
The complement system in regulation of adaptive immunity.补体系统在适应性免疫调节中的作用。
Nat Immunol. 2004 Oct;5(10):981-6. doi: 10.1038/ni1113.
7
Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells.边缘区B细胞将含IgM的免疫复合物转运并沉积到滤泡树突状细胞上。
Int Immunol. 2004 Oct;16(10):1411-22. doi: 10.1093/intimm/dxh142. Epub 2004 Aug 23.
8
Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.狒狒接受来自α1,3-半乳糖基转移酶基因敲除猪的骨髓移植。
Xenotransplantation. 2004 Jul;11(4):361-70. doi: 10.1111/j.1399-3089.2004.00151.x.
9
The role of complement receptors in production of antibodies specific for Galalpha1,3Gal.补体受体在针对α-半乳糖基-1,3-半乳糖特异性抗体产生中的作用。
Transplantation. 2004 Jan 27;77(2):314-6. doi: 10.1097/01.TP.0000101008.13282.FD.
10
Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells.凋亡细胞清除受损会诱导自身反应性抗Sm边缘区B细胞和B-1 B细胞的激活。
J Immunol. 2004 Jan 1;172(1):625-35. doi: 10.4049/jimmunol.172.1.625.

B细胞外在CR1/CR2促进天然抗体产生及抗α-半乳糖产生的B-1细胞的耐受性诱导。

B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells.

作者信息

Shimizu Ichiro, Kawahara Toshiyasu, Haspot Fabienne, Bardwell Philip D, Carroll Michael C, Sykes Megan

机构信息

Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

出版信息

Blood. 2007 Feb 15;109(4):1773-81. doi: 10.1182/blood-2006-02-002386. Epub 2006 Oct 5.

DOI:10.1182/blood-2006-02-002386
PMID:17023586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1794072/
Abstract

B-1b cells produce IgM natural antibodies against alpha1-3Galbeta1-4GlcNAc (alphaGal). These can be tolerized by nonmyeloablative induction of mixed chimerism using alphaGal-positive (alphaGal+) donor marrow. We assessed the role of CR1/2 in this model for induction of tolerance of B-1b cells. Mixed hematopoietic chimerism was induced in alpha1-3galactosyltransferase (GalT-/-) and GalT-/-Cr2-/- mice with alphaGal+ BALB/c marrow donors. Anti-alphaGal Ab and anti-alphaGal Ab-producing B cells became undetectable in GalT-/- chimeras, whereas they persisted in chimeric GalT-/-Cr2-/- mice. To determine whether CR1/2 expression on stromal cells and/or hematopoietic cells was critical for B-1-cell tolerance, we generated GalT-/- radiation chimeras in which CR1/CR2 was expressed on either stromal cells, hematopoietic cells, neither, or both. After induction of mixed chimerism from alphaGal+ allogeneic bone marrow (BM) donors, anti-alphaGal-producing B cells were rendered tolerant in reconstituted recipients expressing only stromal CR1/CR2. Our results suggest a possible role for follicular dendritic cells that pick up immune complexes via CR1/CR2 receptors in the tolerization of B-1b cells.

摘要

B-1b细胞产生针对α1-3半乳糖β1-4N-乙酰葡糖胺（αGal）的IgM天然抗体。使用αGal阳性（αGal+）供体骨髓通过非清髓性诱导混合嵌合体可使这些抗体产生耐受。我们评估了补体受体1/2（CR1/2）在该模型中诱导B-1b细胞耐受的作用。用αGal+ BALB/c骨髓供体在α1-3半乳糖基转移酶（GalT-/-）和GalT-/-Cr2-/-小鼠中诱导混合造血嵌合体。在GalT-/-嵌合体中抗αGal抗体和产生抗αGal抗体的B细胞变得无法检测到，而它们在嵌合的GalT-/-Cr2-/-小鼠中持续存在。为了确定基质细胞和/或造血细胞上CR1/2的表达对于B-1细胞耐受是否至关重要，我们构建了GalT-/-辐射嵌合体，其中CR1/CR2在基质细胞、造血细胞、两者均无或两者上表达。在用αGal+同种异体骨髓（BM）供体诱导混合嵌合体后，在仅表达基质CR1/CR2的重建受体中，产生抗αGal的B细胞产生了耐受。我们的结果表明，通过CR1/CR2受体摄取免疫复合物的滤泡树突状细胞在B-1b细胞耐受中可能发挥作用。