Vogels Neeltje, Posthumus Danielle L A, Mariman Edwin C M, Bouwman Freek, Kester Arnold D M, Rump Patrick, Hornstra Gerard, Westerterp-Plantenga Margriet S
Departments of Human Biology and Methodology and Statistics, Maastricht University, Maastricht, Netherlands.
Am J Clin Nutr. 2006 Oct;84(4):717-24. doi: 10.1093/ajcn/84.4.717.
To improve the effective prevention and treatment of obesity, it is important to focus on body weight (BW) development and its determinants during childhood.
The aim of the present study was to investigate the effects of early development, parental and genetic variables, and behavioral determinants on overweight at 12 y.
In a Dutch cohort of 105 children, anthropometric measurements were conducted from birth until age 7 y. At age 12 y, anthropometric measurements were obtained again, as were measurements of body composition, leptin concentration, 3 polymorphisms, and physical activity, and the Three-Factor Eating Questionnaire was conducted. In addition, parental body mass indexes (BMIs, in kg/m2) and Three-Factor Eating Questionnaire scores were determined.
The children's mean (+/-SD) BMI at 12 y was 19.0 +/- 2.6, and 15.2% were classified as overweight. From the first year of life, BMI tracked significantly with BMI at age 12 y (r = 0.24, P < 0.05). Linear regression analyses showed that a rapid increase in BW during the first year of life, a high BMI of the father, and a high dietary restraint score of the mother were significantly associated with overweight at age 12 y (P < 0.05). No significant genetic relation was observed. In addition, overweight was positively associated with dietary restraint of the child, and percentage body fat was negatively associated with the child's activity score (P < 0.05).
In this homogeneous cohort of normal-weight to moderately overweight children, tracking of BMI during childhood took place from the first year of life. Overweight at age 12 y was predicted by an early rapid increase in BW and parental influences. Overweight during childhood may be maintained or even promoted by a high dietary restraint score and low physical activity.
为改善肥胖的有效预防和治疗，关注儿童期体重（BW）发展及其决定因素很重要。
本研究旨在调查早期发育、父母及遗传变量和行为决定因素对12岁时超重的影响。
在一个由105名儿童组成的荷兰队列中，从出生至7岁进行人体测量。12岁时再次进行人体测量，同时测量身体成分、瘦素浓度、3种多态性和身体活动情况，并进行三因素饮食问卷调查。此外，还测定了父母的体重指数（BMI，单位：kg/m²）和三因素饮食问卷得分。
儿童12岁时的平均（±标准差）BMI为19.0±2.6，15.2%被归类为超重。从生命的第一年起，BMI与12岁时的BMI显著相关（r = 0.24，P < 0.05）。线性回归分析表明，生命第一年体重的快速增加、父亲的高BMI以及母亲的高饮食抑制得分与12岁时的超重显著相关（P < 0.05）。未观察到显著的遗传关系。此外，超重与儿童的饮食抑制呈正相关，身体脂肪百分比与儿童的活动得分呈负相关（P < 0.05）。
在这个体重正常至中度超重儿童的同质队列中，儿童期BMI从生命第一年起就具有追踪性。12岁时的超重可由早期体重快速增加和父母的影响预测。儿童期的超重可能因高饮食抑制得分和低身体活动而维持甚至加重。
