Jung Hyun Jun, Sung Woo Sang, Yeo Soo-Hwan, Kim Hyun Soo, Lee In-Seon, Woo Eun-Rhan, Lee Dong Gun
Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.
Arch Pharm Res. 2006 Sep;29(9):746-51. doi: 10.1007/BF02974074.
Amentoflavone is a plant bif avonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.
穗花杉双黄酮是一种植物双黄酮，从卷柏（Selaginella tamariscina (Beauv.) spring）全株的乙酸乙酯提取物中分离得到。利用包括DEPT、HMQC和HMBC在内的一维和二维核磁共振光谱确定其结构。穗花杉双黄酮对几种致病真菌菌株表现出强大的抗真菌活性，但对人红细胞的溶血作用非常低。特别是，穗花杉双黄酮诱导白色念珠菌细胞内海藻糖的积累，作为对该药物的应激反应，并破坏了在发病过程中形成假菌丝的二态转变。总之，穗花杉双黄酮作为抗真菌药物开发的先导化合物具有巨大潜力。
