通过 NMR 光谱法测定卷柏中的卷柏素 G 和 H 的结构。
Structure determination of selaginellins G and H from Selaginella pulvinata by NMR spectroscopy.
出版信息
Magn Reson Chem. 2010 Aug;48(8):656-9. doi: 10.1002/mrc.2623.
DOI:10.1002/mrc.2623
PMID:20623720
Abstract
Selaginellins G (1) and H (2), two new selaginellin derivatives, were isolated from the whole plant of Selaginella pulvinata. Their structures were elucidated, and complete assignments of the (1)H and (13)C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, COSY and ROESY). Compound 1 displayed good antifungal activity against Candida albicans with an IC(50) value of 5.3 microg/ml.
摘要
从卷柏全草中分离得到两个新的卷柏素衍生物 Selaginellins G（1）和 H（2）。通过 1D 和 2D NMR 实验（HSQC、HMBC、COSY 和 ROESY）阐明了它们的结构，并对（1）H 和（13）C NMR 光谱数据进行了完全归属。化合物 1 对白色念珠菌显示出良好的抗真菌活性，IC（50）值为 5.3 μg/ml。
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