Gao Xinyu, Zhang Ni, Xie Weidong
State Key Laboratory of Chemical Oncogenomics, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Shenzhen Key Laboratory of Health Science and Technology, Institute of Biopharmaceutical and Health, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Molecules. 2024 Mar 2;29(5):1128. doi: 10.3390/molecules29051128.
(Lemée and H.Lév.) S.Y.Hu, indigenous to the southern regions of China, is an evergreen tree belonging to the genus Taxus of the Taxaceae family. Owing to its content of various bioactive compounds, it exhibits multiple pharmacological activities and has been widely applied in clinical medicine. This article comprehensively discusses the current state of cultivation, chemical constituents, applications in the pharmaceutical field, and the challenges faced by The paper begins by detailing the ecological distribution of , aiming to provide an in-depth understanding of its origin and cultivation overview. In terms of chemical composition, the article thoroughly summarizes the extracts and monomeric components of , unveiling their pharmacological activities and elucidating the mechanisms of action based on the latest scientific research, as well as their potential as lead compounds in new drug development. The article also addresses the challenges in the research, such as the difficulties in extracting and synthesizing active components and the need for sustainable utilization strategies. In summary, is a rare species important for biodiversity conservation and demonstrates significant research and application potential in drug development and disease treatment.
（勒梅和H.莱夫）中国南方本土的南方红豆杉是红豆杉科红豆杉属的一种常绿乔木。由于其含有多种生物活性化合物，它具有多种药理活性，并已在临床医学中广泛应用。本文全面探讨了南方红豆杉的栽培现状、化学成分、在制药领域的应用以及面临的挑战。文章首先详细介绍了南方红豆杉的生态分布，旨在深入了解其起源和栽培概况。在化学成分方面，文章全面总结了南方红豆杉的提取物和单体成分，揭示了它们的药理活性，并根据最新科学研究阐明其作用机制，以及它们作为新药开发先导化合物的潜力。文章还讨论了南方红豆杉研究中的挑战，如活性成分提取和合成的困难以及可持续利用策略的需求。总之，南方红豆杉是一种对生物多样性保护很重要的珍稀物种，在药物开发和疾病治疗方面具有显著的研究和应用潜力。
