Furihata C, Hirose K, Matsushima T
Department of Molecular Oncology, University of Tokyo, Japan.
Mutat Res. 1991 Jan;262(1):73-6. doi: 10.1016/0165-7992(91)90109-h.
Induction of unscheduled DNA synthesis (UDS) as a marker of genotoxicity and induction of ornithine decarboxylase (ODC) activity as a marker of cell proliferative activity by omeprazole were determined in the glandular stomach mucosa of male F344 rats after oral administration. Commercial enteric-coated omeprazole (Losec) at doses of 30 and 100 mg/kg body weight induced a dose-dependent increase in UDS but not replicative DNA synthesis in the pyloric mucosa of rat stomach 4 h after its administration. Dose-dependent significant induction of ODC activity was observed in fundic and pyloric mucosa with a maximum 8 h after administration of omeprazole at doses of 37.5-100 mg/kg body weight. These results show that omeprazole has genotoxicity and cell proliferative activity in the rat glandular stomach mucosa.
口服给药后，在雄性F344大鼠的腺胃黏膜中测定了奥美拉唑诱导的非程序性DNA合成（UDS）作为遗传毒性标志物以及鸟氨酸脱羧酶（ODC）活性诱导作为细胞增殖活性标志物的情况。给予商业肠溶包衣奥美拉唑（洛赛克），剂量为30和100mg/kg体重，给药4小时后，大鼠胃幽门黏膜中的UDS呈剂量依赖性增加，但复制性DNA合成未增加。在给予37.5 - 100mg/kg体重的奥美拉唑后8小时，在胃底和幽门黏膜中观察到ODC活性呈剂量依赖性显著诱导。这些结果表明，奥美拉唑在大鼠腺胃黏膜中具有遗传毒性和细胞增殖活性。
