Popova N K, Naumenko V S, Plyusnina I Z
Behavioral Neurogenetics Laboratory, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk.
Neurosci Behav Physiol. 2007 Jul;37(6):631-5. doi: 10.1007/s11055-007-0062-z.
Experiments were performed on Norwegian rats selected over more than 59 generations for high and low levels of high-affective defensive aggressivity and on highly aggressive (offensive) Tg8 mice with irreversible monoamine oxidase A knockout. There were significant differences in the functional state and expression of 5-HT(1A) receptors between highly aggressive and non-aggressive animals. Functional activity assessed in terms of hypothermia evoked by a 5-HT(1A) agonist was significantly greater in non-aggressive rats and mice than in aggressive animals. The high level of functional activity in non-aggressive rats coincided with a greater level of expression of 5-HT(1A) receptors in the midbrain. The level of 5-HT(1A) receptor mRNA in aggressive mice was unchanged in the midbrain and hypothalamus and was increased in the frontal cortex and amygdaloid complex. These results led to the conclusion that 5-HT(1A) receptors play a significant role in the mechanisms of genetic predisposition to aggressive behavior.
实验是在经过59代以上选育的具有高、低水平高情感防御性攻击行为的挪威大鼠以及具有不可逆单胺氧化酶A基因敲除的高攻击性（进攻性）Tg8小鼠身上进行的。高攻击性和非攻击性动物之间5-HT(1A)受体的功能状态和表达存在显著差异。用5-HT(1A)激动剂诱发的体温过低来评估的功能活性，在非攻击性大鼠和小鼠中比在攻击性动物中显著更高。非攻击性大鼠的高功能活性水平与中脑中5-HT(1A)受体的更高表达水平相一致。攻击性小鼠中脑和下丘脑的5-HT(1A)受体mRNA水平未发生变化，而额叶皮质和杏仁复合体中的水平有所增加。这些结果得出结论，5-HT(1A)受体在攻击行为的遗传易感性机制中起重要作用。
