Hunter Martin, Backman Vadim, Popescu Gabriel, Kalashnikov Maxim, Boone Charles W, Wax Adam, Gopal Venkatesh, Badizadegan Kamran, Stoner Gary D, Feld Michael S
G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Phys Rev Lett. 2006 Sep 29;97(13):138102. doi: 10.1103/PhysRevLett.97.138102. Epub 2006 Sep 28.
Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.
从生物组织散射的光可以呈现出反幂律光谱成分。我们基于亚微米级组织折射率的玻恩近似和冯·卡门（自仿射）空间相关性开发了一个模型来解释这一现象。该模型应用于从正常和致癌物处理大鼠的切除食管获得的光散射光谱。用于拟合发育异常组织部位光谱的幂律指数明显小于正常部位的指数，这表明组织自相似性的变化可以作为癌前病变的潜在生物标志物。
