IISER-Kolkata, BCKV Main Campus, Mohanpur, Nadia, West Bengal, India.
Opt Lett. 2013 Jan 15;38(2):211-3. doi: 10.1364/OL.38.000211.
Multiresolution analysis on the spatial refractive index inhomogeneities in the epithelium and connective tissue regions of a human cervix reveals a clear signature of multifractality. Importantly, the derived multifractal parameters, namely, the generalized Hurst exponent and the width of the singularity spectrum, derived via multifractal detrended fluctuation analysis, shows interesting differences between tissues having different grades of precancers. The refractive-index fluctuations are found to be more anticorrelated, and the strength of multifractality is observed to be considerably stronger in the higher grades of precancers. These observations on the multifractal nature of tissue refractive-index variations may prove to be valuable for developing light-scattering approaches for noninvasive diagnosis of precancer and early-stage cancer.
对人宫颈上皮组织和结缔组织区域的空间折射率非均匀性进行多分辨率分析，揭示了多重分形的清晰特征。重要的是，通过多重分形去趋势波动分析得到的衍生多重分形参数，即广义赫斯特指数和奇异谱的宽度，在具有不同癌前病变程度的组织之间表现出有趣的差异。发现折射率波动的相关性更强，并且在较高等级的癌前病变中，多重分形的强度明显更强。这些关于组织折射率变化的多重分形性质的观察结果可能对开发用于非侵入性诊断癌前病变和早期癌症的光散射方法具有重要意义。
