Ghosh Sayantan, Soni Jalpa, Purwar Harsh, Jagtap Jaidip, Pradhan Asima, Ghosh Nirmalya, Panigrahi Prasanta K
School of Physics, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
Opt Express. 2011 Sep 26;19(20):19717-30. doi: 10.1364/OE.19.019717.
The fluctuations in the elastic light scattering spectra of normal and dysplastic human cervical tissues analyzed through wavelet transform based techniques reveal clear signatures of self-similar behavior in the spectral fluctuations. The values of the scaling exponent observed for these tissues indicate the differences in the self-similarity for dysplastic tissues and their normal counterparts. The strong dependence of the elastic light scattering on the size distribution of the scatterers manifests in the angular variation of the scaling exponent. Interestingly, the spectral fluctuations in both these tissues showed multi-fractality (non-stationarity in fluctuations), the degree of multi-fractality being marginally higher in the case of dysplastic tissues. These findings using the multi-resolution analysis capability of the discrete wavelet transform can contribute to the recent surge in the exploration for non-invasive optical tools for pre-cancer detection.
