Straube Werner L, Tanaka Elly M
Max-Planck Institute of Molecular Biology and Genetics, Dresden, Germany.
Artif Organs. 2006 Oct;30(10):743-55. doi: 10.1111/j.1525-1594.2006.00296.x.
In contrast to mammals, some fish and amphibians have retained the ability to regenerate complex body structures or organs, such as the limb, tail, eye lens, or even parts of the heart. One major difference in the response to injury is the appearance of a mesenchymal growth zone or blastema in these regenerative species instead of the scarring seen in mammals. This blastema is thought to largely derive from the dedifferentiation of various functional cell types, such as skeletal muscle, dermis, and cartilage. In the case of multinucleated skeletal muscle fibers, cell cycle reentry into S-phase as well as fragmentation into mononucleated progenitors is observed both in vitro and in vivo.
与哺乳动物不同，一些鱼类和两栖动物保留了再生复杂身体结构或器官的能力，如肢体、尾巴、晶状体，甚至部分心脏。这些再生物种对损伤反应的一个主要差异是出现了间充质生长区或芽基，而不是哺乳动物中所见的瘢痕形成。这种芽基被认为主要源自各种功能细胞类型的去分化，如骨骼肌、真皮和软骨。在多核骨骼肌纤维的情况下，在体外和体内均观察到细胞周期重新进入S期以及分裂成单核祖细胞。
