Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Canada M5G 1L7.
Department of Molecular Genetics, University of Toronto, Toronto, Canada M5G 1A8.
Open Biol. 2020 Sep;10(9):200194. doi: 10.1098/rsob.200194. Epub 2020 Sep 30.
Digit tip regeneration is one of the few examples of true multi-tissue regeneration in an adult mammal. The key step in this process is the formation of the blastema, a transient proliferating cell mass that generates the different cell types of the digit to replicate the original structure. Failure to form the blastema results in a lack of regeneration and has been postulated to be the reason why mammalian limbs cannot regrow following amputation. Understanding how the blastema forms and functions will help us to determine what is required for mammalian regeneration to occur and will provide insights into potential therapies for mammalian tissue regeneration and repair. This review summarizes the cellular and molecular mechanisms that influence murine blastema formation and govern digit tip regeneration.
指尖再生是成年哺乳动物中少数真正的多组织再生的例子之一。这个过程的关键步骤是形成芽基，这是一种短暂增殖的细胞团，它产生指尖的不同细胞类型，以复制原始结构。如果不能形成芽基，就会导致再生失败，据推测这就是哺乳动物肢体在截肢后不能再生的原因。了解芽基的形成和功能将有助于我们确定哺乳动物再生所需的条件，并为哺乳动物组织再生和修复的潜在治疗方法提供启示。本综述总结了影响小鼠芽基形成和控制指尖再生的细胞和分子机制。
