Matura Mihaly, Sköld Maria, Börje Anna, Andersen Klaus E, Bruze Magnus, Frosch Peter, Goossens An, Johansen Jeanne D, Svedman Cecilia, White Ian R, Karlberg Ann-Therese
Dermatochemistry and Skin Allergy, Department of Chemistry, Göteborg University, Gothenburg, Sweden.
Contact Dermatitis. 2006 Nov;55(5):274-9. doi: 10.1111/j.1600-0536.2006.00939.x.
Limonene, one of the most often used fragrance terpenes in any kind of scented products, is prone to air-oxidation. The oxidation products formed have a considerable sensitizing potential. In previous patch test studies on consecutively tested dermatitis patients, oxidized R-limonene has been proven to be a good and frequent indicator of fragrance-related contact allergy. The current study extends these investigations to 6 European clinics of dermatology, where the oxidation mixture of both enantiomers of limonene (R and S) have been tested in 2411 dermatitis patients. Altogether, 63 out of 2411 patients tested (2.6%) reacted to 1 or both the oxidized limonene preparations. Only 2.3% reacted to the oxidized R-limonene and 2.0% to the oxidized S-limonene. In 57% of the cases, simultaneous reactions were observed to both oxidation mixtures. Concomitant reactions to the fragrance mix, colophonium, Myroxylon pereirae, and fragrance-related contact allergy were common in patients reacting to 1 or both the oxidized limonene enantiomers. Our study provides clinical evidence for the importance of oxidation products of limonene in contact allergy. It seems advisable to screen consecutive dermatitis patients with oxidized limonene 3% petrolatum, although this patch test material is not yet commercially available.
柠檬烯是各类香氛产品中最常用的香料萜烯之一，易于发生空气氧化。所形成的氧化产物具有相当大的致敏潜力。在先前对连续检测的皮炎患者进行的斑贴试验研究中，已证明氧化型R-柠檬烯是香料相关接触性过敏的一个良好且常见的指标。当前的研究将这些调查扩展至6家欧洲皮肤科诊所，在那里对2411名皮炎患者进行了柠檬烯两种对映体（R和S）的氧化混合物测试。在2411名接受测试的患者中，共有63名（2.6%）对1种或两种氧化型柠檬烯制剂有反应。仅2.3%的患者对氧化型R-柠檬烯有反应，2.0%的患者对氧化型S-柠檬烯有反应。在57%的病例中，观察到对两种氧化混合物同时有反应。在对1种或两种氧化型柠檬烯对映体有反应的患者中，同时对香料混合物、松香脂、秘鲁香脂和香料相关接触性过敏有反应很常见。我们的研究为柠檬烯氧化产物在接触性过敏中的重要性提供了临床证据。用3%凡士林氧化型柠檬烯对连续的皮炎患者进行筛查似乎是可取之举，尽管这种斑贴试验材料尚未商业化可得。
