Department of Dermatology, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden.
Contact Dermatitis. 2013 Apr;68(4):214-23. doi: 10.1111/cod.12036.
Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients.
To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting.
Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia.
Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen.
Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.
柠檬烯是一种常见的香料萜烯，其纯品既非过敏原，也属于非常弱的过敏原。然而，柠檬烯在暴露于空气中时会自动氧化，其氧化产物会引起接触过敏。已在多中心研究中对氧化的 R-柠檬烯进行斑贴试验，结果显示连续患者中有 2-3%的阳性斑贴试验反应。
研究是否可以使用 3.0%（主要半抗原柠檬烯过氧化物（Lim-OOHs）含量为 0.33%）的氧化 R-柠檬烯（油膏）作为国际环境下接触过敏检测的有用工具。
在丹麦、英国、新加坡、西班牙、瑞典和澳大利亚的 2900 例连续皮炎患者中进行了氧化 R-柠檬烯 3.0%（油膏）（Lim-OOHs 0.33%）的测试。
总体而言，5.2%（范围为 2.3-12.1%）的患者对氧化 R-柠檬烯出现阳性斑贴试验反应。在 7.0%（范围为 0-24%）的患者中发现可疑反应。很少有刺激性反应。
含有特定含量 Lim-OOHs 0.33%的 3.0%油膏氧化 R-柠檬烯是一种用于检测皮炎患者接触过敏的标准化且有用的工具。如果没有进行特定的测试，许多对氧化 R-柠檬烯呈阳性斑贴试验反应的患者将不会被告知他们的香料过敏。
