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巴氏甲烷八叠球菌中通过涉及两个甲基化反应的途径进行血红素生物合成。

Heme biosynthesis in Methanosarcina barkeri via a pathway involving two methylation reactions.

作者信息

Buchenau Bärbel, Kahnt Jörg, Heinemann Ilka U, Jahn Dieter, Thauer Rudolf K

机构信息

Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, D-35043 Marburg, Germany.

出版信息

J Bacteriol. 2006 Dec;188(24):8666-8. doi: 10.1128/JB.01349-06. Epub 2006 Oct 6.

DOI:10.1128/JB.01349-06
PMID:17028275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698242/
Abstract

The methanogenic archaeon Methanosarcina barkeri synthesizes protoheme via precorrin-2, which is formed from uroporphyrinogen III in two consecutive methylation reactions utilizing S-adenosyl-L-methionine. The existence of this pathway, previously exclusively found in the sulfate-reducing delta-proteobacterium Desulfovibrio vulgaris, was demonstrated for M. barkeri via the incorporation of two methyl groups from methionine into protoheme.

摘要

产甲烷古菌巴氏甲烷八叠球菌通过前咕啉-2合成原血红素，前咕啉-2由尿卟啉原III利用S-腺苷-L-甲硫氨酸经两个连续的甲基化反应形成。这条先前仅在硫酸盐还原δ-变形菌普通脱硫弧菌中发现的途径，通过将甲硫氨酸中的两个甲基掺入原血红素，在巴氏甲烷八叠球菌中得到了证实。

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J Bacteriol. 2006 Dec;188(24):8666-8. doi: 10.1128/JB.01349-06. Epub 2006 Oct 6.
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本文引用的文献

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Sulphate respiration from hydrogen in Desulfovibrio bacteria: a structural biology overview.脱硫弧菌中氢气的硫酸盐呼吸作用：结构生物学概述
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