Engels B M, Hutvagner G
Division of Gene regulation and Expression, College of Life Sciences, University of Dundee, Dundee, UK.
Oncogene. 2006 Oct 9;25(46):6163-9. doi: 10.1038/sj.onc.1209909.
MicroRNAs (miRNAs) are abundant regulatory RNAs involved in the regulation of many key biological processes. Recent advances in understanding the mechanism of RNA interference and miRNA-mediated mechanisms shed light on major principals of the formation of the regulatory complex and provide models to explain how these small regulatory RNA species interfere with gene expression and how they influence the translational status of the transcriptome.
微小RNA（miRNA）是丰富的调控RNA，参与许多关键生物学过程的调控。在理解RNA干扰机制和miRNA介导机制方面的最新进展，揭示了调控复合物形成的主要原理，并提供了模型来解释这些小调控RNA物种如何干扰基因表达以及它们如何影响转录组的翻译状态。
