Becker Y
Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Virus Genes. 1990 Sep;4(3):267-82. doi: 10.1007/BF00265636.
Antigenic domains and RGD-like sequences in the E glycoprotein of the flaviviruses Japanese encephalitis virus, yellow fever virus, West Nile virus, dengue type 4 virus, and tick-borne encephalitis virus were analyzed by computer programs that provide information on the physical properties of the polypeptides. The use of computer programs for the development of vaccines based on the synthesis of antigenic peptides is discussed. Synthetic viral peptides are proposed to be used for topical application so as to interfere with the virus-cell interaction. Viral peptides with antigenic epitopes to protect against dengue virus infection without enhancing pathogenesis may also be developed on the basis of the computer analysis.
利用能提供多肽物理性质信息的计算机程序，分析了黄病毒属的日本脑炎病毒、黄热病毒、西尼罗河病毒、登革4型病毒和蜱传脑炎病毒E糖蛋白中的抗原结构域和类RGD序列。讨论了利用计算机程序开发基于抗原肽合成的疫苗。建议将合成病毒肽用于局部应用，以干扰病毒与细胞的相互作用。基于计算机分析，也可能开发出具有抗原表位、可预防登革病毒感染且不增强发病机制的病毒肽。
