Sivaprasad Ganesabaskaran, Perumal Paramasivan T, Prabavathy Vaiyapuri R, Mathivanan Narayanasamy
Organic Chemistry Division, Central Leather Research Institute, Chennai 600 020, India.
Bioorg Med Chem Lett. 2006 Dec 15;16(24):6302-5. doi: 10.1016/j.bmcl.2006.09.019. Epub 2006 Oct 6.
A series of pyrazolylbisindole derivatives have been synthesized by reacting substituted pyrazole aldehydes with substituted indoles using phosphotungstic acid, a Keggin type heteropoly acid as catalyst. The synthesized pyrazolylbisindoles were evaluated for anti-microbial activities. The effect of pyrazolylbisindoles on the mycelial growth of plant pathogenic fungi is revealed. Entries 3c and 3d emerged as the most interesting compounds in this series exhibiting excellent anti-fungal activity.
通过使用磷钨酸（一种Keggin型杂多酸）作为催化剂，使取代的吡唑醛与取代的吲哚反应，合成了一系列吡唑基双吲哚衍生物。对合成的吡唑基双吲哚进行了抗菌活性评估。揭示了吡唑基双吲哚对植物病原真菌菌丝生长的影响。在该系列中，条目3c和3d成为最具吸引力的化合物，表现出优异的抗真菌活性。
